For me it’s Super Metroid. I have played Zero Mission, Fusion, Metroid: Samus Returns (3ds) and Metroid prime remaster, three of these games are remake/remaster. So you can see why I’m hesitant to start Super Metroid, I’m sure that game still holds up, but playing it with modern controls annd other bells and whistles would be more ideal.
Twilight princess got a HD remaster though.