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Joined 1 year ago
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Cake day: July 4th, 2023

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  • My wife and have been playing the hell out of Diablo 4 (no pun intended). It has just enough elements from D2 that characters feel open and alive but is accessible enough for my wife (who would not have liked D2) to enjoy trying to come up with new builds.

    Season 1 starts in two days and I’m very excited.

    Other than that I’ve been playing Curse The Case of the Golden Idol. It is a sequel of sorts to Obra Dinn, but done in smaller scenarios that can be completed in 30 minutes or so each. I love going from what the hell is happening here too understanding fully all the implications in that time. Really feels like detective work.

    Edit: don’t even know the name of the game I’m playing haha




  • We are starting to see the first drugs on the market that utilize the amyloid beta pathway in some fashion because research in the 90’s and 2000’s were absolutely convinced that this pathway was the lynchpin to the disease. My understanding of the disease (I studied biotech but not Alzheimer’s specifically) is that amyloid beta plaques are more of a side effect of whatever is really going on than the main show. And unfortunately the mechanism of dementia in general is not really well understood, Alzheimer’s included.

    These sobering results are not really that surprising because treating the amyloid beta plaques after they have formed is sort of like trying to prevent spoiled meat by removing the maggots that have accumulated on it.