There was an issue with the 11th gen mainboards (the first Framework laptop generation) that if the laptop was left unplugged for too long (like, weeks), the internal RTC battery would deplete and the system would become unbootable without resetting the mainboard. They fixed it in the next generation, though.
As in turn it off or on, or change the curve itself? The option to turn it off or on is in the main Settings -> Mouse and Touchpad page with GNOME 44, labeled “Mouse Acceleration.” Which is, in my opinion, easier than Windows’ obscure Windows 95-style pop-up for “additional mouse settings” and then “enhance pointer precision.”